The Difference Culture Makes

The Difference All-Difference Makes

We perform a comprehensive theoretical and experimental analysis of the use of all-different constraints. We prove that generalized arc-consistency on such constraints lies between neighborhood inverse consistency and, under a simple restriction, path inverse consistency on the binary representation of the problem. By generalizing the arguments of Kondrak and van Beek, we prove that a search al...

Rewiring makes the difference

While canonical pathways and regulatory networks provide a representation of molecular interactions in the cell that appears static and immutable, actual regulatory pathways are anything but. Rather, they appear to reconfigure dynamically as a function of the specific molecular context in which they operate. This was shown initially in yeast (Luscombe et al, 2004) and more recently in mammalian...

Race: The Difference That Makes a Difference

During the last two decades, critical enquiry into the nature of race has begun to enter the philosophical mainstream. The same period has also witnessed the emergence of an increasingly visible discourse about the nature of information within a diverse range of popular and academic settings. What is yet to emerge, however, is engagement at the interface of the two disciplines – critical race t...

“Double hit” makes the difference

Multiple structural, biochemical and in vivo studies have solidified the role that histone acetyltransferases (HATs) play in regulation of the p53 pathway. 1 HATs are known to modulate p53 functions in many ways, from regulating its stability to promoting acetyla-tion-dependent interactions with DnA as well as various co-factors and chromatin modi-fiers. 1 Of these, p300, CBP, PCAF and Tip60 ar...

The brain makes a difference